I bought the Eclipse Phase rulebook after skimming over the free PDF, which for me happens very rarely - that's how impressed I was with it.
However there are some issues I'd like to comment on and improvements to suggest.
Superficial stuff: First, the artwork in the core rulebook. Artwork has the important (although not vital to the overall enjoyment of the game) task of conveying the setting. While the chapter artwork with its sci-fi panoramas is quite evocative the "random" pictures scattered throughout the book are very generic in nature. I feel they don't convey anything in particular apart from the "Kubrick style" sterile sci-fi future married to certain trends seen in manga/anime. This visual style has: 1. been done to death 2. a very bland, impersonal appearance (something that Kubrick among others, used to convey the impersonal, detached relationship of man-man and man-environment in the future). Now point 2 seems to contradict the apparent lack of a tangible atmosphere, but in reality it does not. Bland is still bland, no matter how you put it and no matter what overall artistic impression you want to impart.
In my opinion Eclipse Phase needs more character, which means that humans in the artwork should look less like hi tech dolls (even if that's what they partly are) and more, well, human. The same goes for environments and gear really.
Human reproduction. This issue seems to be almost ignored in the rulebook, and its unclear how reproduction functions (with the space constraints) if everyone is essentially immortal. People obviously reproduce somewhere (apart from certain factions) and the availability of food and medicine means that populations increase at least as much as during late 20th/21th century levels. If reproduction is forbidden (?) that means human society is essentially a bunch of jaded immortals looking for their next fix. Now while it makes sense that some parts of the universe look like this, its highly unlikely (actually impossible) that its the same everywhere.
Solution: expand on the variety and details of various lifestyles of people in the EP universe, in further supplements
Anti-religion (Christianity, Judaism but curiously not Islam or Budhhism), anti-nation state bias.
For a setting that takes itself as seriously as EP, for me this was for me the most disappointing aspect of the universe overall. The death of religion and nation states has been proclaimed many times in the last century (nation state) and several centuries (religion) and has proven to be absolute nonsense time and time again.
The reasons for it are beyond the scope of this post, but everything in the real world points that religion and nations are here to stay for the foreseeable future. Its quite unrealistic to assume that they would cease exist as promptly as EP puts it.
Especially in the case of religion, Christianity and Judaism in particular. The several passages that deal in this matter are borderline bigotry with a strange twist when Islam is concerned, which is arguably the most conservative and restrictive of the three yet somehow manages to "reform"?
Apart from the almost offensive tone of the several passages the point remains - they make absolutely no sense. Especially in the situation of tragedy that is the Fall, where people are very likely to cling to the familiar and comforting identities that religion/nations provide.
I think this entire chapter should be rewritten with a more realistic viewpoint that isn't burdened with liberal/secular bias.
Sorry for the /very/ long post.