Using Maptools or Roll 20 with voice, such as SKYPE or Ventrilo. Best time frame for me, being PST, is 9 to midnight EST, but I could probably make 8 PM EST most of the time.
I do have a good bit of play experience, but that was over a year ago, so need to refresh my memory. I have the third printing book. I also have the first printing, if that is important.